C₂₄H₂₁N₃O₂

Base Information

• Chemical Name: C₂₄H₂₁N₃O₂
• CAS No.: 87923-29-3
• Molecular Formula: C₂₄H₂₁N₃O₂
• Molecular Weight: 383.45
• Mol file: 87923-29-3.mol

Synonyms:C₂₄H₂₁N₃O₂

Chemical Property of C₂₄H₂₁N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₁N₃O₂

There total 18 articles about C₂₄H₂₁N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2R,4R,5R)-4-Bromo-1-methyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-2-carbonyl chloride (87923-12-4) → C24H21N3O2 (87923-29-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 4.2 g / tetrahydrofuran; diethyl ether / 0.5 h

2: 72 percent / Zn / acetic acid / 24 h / 50 °C

3: 67 percent / NaBH₄, NaHCO₃ / H₂O / 1 h / Ambient temperature

4: 83 percent / diethyl ether; benzene / 0.5 h / -78 °C

5: 58 percent / CrO₃ / CH₂Cl₂; pyridine / 1 h / Ambient temperature

6: 97 percent / TiCl₄, Zn-Cu / 1,2-dimethoxy-ethane / 1 h / Heating

7: pyridinium hydrobromide perbromide / CCl₄ / 12 h / Ambient temperature

8: 42 percent / LiF, Li₂CO₃ / hexamethylphosphoric acid triamide / 20 h / 60 - 65 °C

9: 20 mg / benzene; ethyl acetate / 48 h / Heating

With chromium(VI) oxide; sodium tetrahydroborate; pyridinium hydrobromide perbromide; titanium tetrachloride; lithium carbonate; copper; sodium hydrogencarbonate; lithium fluoride; zinc; In tetrahydrofuran; pyridine; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid; ethyl acetate; benzene;

DOI:10.1021/ja00364a030

Reference yield:

(1S,2R,4R,5R)-4-Bromo-1-methyl-7-oxo-6-oxa-bicyclo[3.2.1]octane-2-carboxylic acid (53777-68-7,87982-77-2) → C24H21N3O2 (87923-29-3)

Guidance literature:

Multi-step reaction with 10 steps

1: SOCl₂

2: 4.2 g / tetrahydrofuran; diethyl ether / 0.5 h

3: 72 percent / Zn / acetic acid / 24 h / 50 °C

4: 67 percent / NaBH₄, NaHCO₃ / H₂O / 1 h / Ambient temperature

5: 83 percent / diethyl ether; benzene / 0.5 h / -78 °C

6: 58 percent / CrO₃ / CH₂Cl₂; pyridine / 1 h / Ambient temperature

7: 97 percent / TiCl₄, Zn-Cu / 1,2-dimethoxy-ethane / 1 h / Heating

8: pyridinium hydrobromide perbromide / CCl₄ / 12 h / Ambient temperature

9: 42 percent / LiF, Li₂CO₃ / hexamethylphosphoric acid triamide / 20 h / 60 - 65 °C

10: 20 mg / benzene; ethyl acetate / 48 h / Heating

With chromium(VI) oxide; sodium tetrahydroborate; thionyl chloride; pyridinium hydrobromide perbromide; titanium tetrachloride; lithium carbonate; copper; sodium hydrogencarbonate; lithium fluoride; zinc; In tetrahydrofuran; pyridine; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid; ethyl acetate; benzene;

DOI:10.1021/ja00364a030

Reference yield:

phenyllithium (591-51-5) → C24H21N3O2 (87923-29-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 84 percent / diethyl ether; benzene / 0.5 h / -78 °C

2: 190 mg / CrO₃ / CH₂Cl₂; pyridine / 1 h / Ambient temperature

3: 135 mg / TiCl₄, Zn-Cu / 1,2-dimethoxy-ethane / 1 h / Heating

4: pyridinium hydrobromide perbromide / CCl₄ / 12 h / Ambient temperature

5: t-BuOK / dimethylsulfoxide / 0.75 h / Ambient temperature

6: benzene / Heating

With chromium(VI) oxide; potassium tert-butylate; pyridinium hydrobromide perbromide; titanium tetrachloride; copper; zinc; In pyridine; tetrachloromethane; 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;

DOI:10.1021/ja00364a030

upstream raw materials:

4-Phenyl-1,2,4-triazolidine-3,5-dione

1,3-dimethyl-2-phenylcyclooctatetraene

phenyllithium

(3aR,7aS)-3,7a-Dimethyl-3a,4,7,7a-tetrahydro-3H-isobenzofuran-1-one