5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

Base Information

Chemical Name:5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline
CAS No.:1422193-05-2
Molecular Formula:C₁₉H₁₉F₃N₂O₂S
Molecular Weight:396.433
Hs Code.:

Synonyms:5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

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Chemical Property of 5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

Chemical Property:

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Technology Process of 5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

There total 5 articles about 5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-trifluoromethyl-2-nitrobenzylidene)-1-(phenylsulfonyl)piperidine

: 1422193-05-2
5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

Guidance literature:: With iron; acetic acid; In ethanol; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol400137q

Reference yield:

: 1422192-51-5
diethyl 2-nitro-4-(trifluoromethyl)benzylphosphonate

: 1422193-05-2
5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / Inert atmosphere

4.1: acetic acid; iron / ethanol / 2 h / 80 °C / Inert atmosphere

With n-butyllithium; iron; acetic acid; triethylamine; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/ol400137q

Reference yield:

: 162333-02-0
1-(bromomethyl)-4-(trifluoromethyl)-2-nitrobenzene

: 1422193-05-2
5-trifluoromethyl-2-((1-(phenylsulfonyl)piperidin-3-ylidene)methyl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 24 h / 120 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere

2.2: 16 h / -78 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / Inert atmosphere

5.1: acetic acid; iron / ethanol / 2 h / 80 °C / Inert atmosphere

With n-butyllithium; iron; acetic acid; triethylamine; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; toluene;
DOI:10.1021/ol400137q