Technology Process of (4R,5R)-5-Dibenzylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-2-methylene-pentanoic acid ethyl ester
There total 7 articles about (4R,5R)-5-Dibenzylamino-5-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-2-methylene-pentanoic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; ammonium chloride; zinc;
In
tetrahydrofuran;
at 60 ℃;
for 0.75h;
DOI:10.1039/a708594j
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 2,6-lutidine / CH2Cl2 / 0.75 h / -50 - -10 °C
2: 80 percent / LiN3 / dimethylformamide / 3 h / 18 °C
3: 100 percent / LAH / tetrahydrofuran / 3 h / 18 - 65 °C
4: 90 percent / K2CO3 / acetonitrile / 14 h / 60 °C
5: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 to 0 deg C, 1 h, 2.) CH2Cl2
6: 87 percent / Zn, H2O, NH4Cl / tetrahydrofuran / 0.75 h / 60 °C
With
2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium azide; oxalyl dichloride; water; potassium carbonate; ammonium chloride; dimethyl sulfoxide; triethylamine; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/a708594j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / LiN3 / dimethylformamide / 3 h / 18 °C
2: 100 percent / LAH / tetrahydrofuran / 3 h / 18 - 65 °C
3: 90 percent / K2CO3 / acetonitrile / 14 h / 60 °C
4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 to 0 deg C, 1 h, 2.) CH2Cl2
5: 87 percent / Zn, H2O, NH4Cl / tetrahydrofuran / 0.75 h / 60 °C
With
lithium aluminium tetrahydride; lithium azide; oxalyl dichloride; water; potassium carbonate; ammonium chloride; dimethyl sulfoxide; triethylamine; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/a708594j