6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

Base Information

Chemical Name:6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline
CAS No.:98510-05-5
Molecular Formula:C₃₂H₂₈F₃N₃O₄
Molecular Weight:575.587
Hs Code.:

6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5-<m-(trifluoromethyl)phenoxy>-4-vinylquinoline

Synonyms:6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

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Chemical Property of 6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

Chemical Property:

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Technology Process of 6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

There total 4 articles about 6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63460-47-9
2-(4-iodopentyl)-1,3-isoindolinedione

: 6-Methoxy-5-(3-trifluoromethyl-phenoxy)-4-vinyl-quinolin-8-ylamine

: 98510-05-5
6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 90 ℃; Yield given;
DOI:10.1021/jm00149a004

Reference yield:

: 82333-37-7
6-methoxy-4-methyl-8-nitro-5-<3-(trifluoromethyl)phenoxy>quinoline

: 98510-05-5
6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / acetic acid, selenium dioxide / dioxane; acetic anhydride / Heating

2: 72 percent / tetrahydrofuran; hexane / 2 h / Ambient temperature

3: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

4: triethylamine / dimethylformamide / 90 °C

With hydrogenchloride; tin; selenium(IV) oxide; acetic acid; triethylamine; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; acetic anhydride; N,N-dimethyl-formamide;
DOI:10.1021/jm00149a004

Reference yield:

: 98509-97-8
6-methoxy-8-nitro-5--4-vinylquinoline

: 98510-05-5
6-methoxy-8-<(4-phthalimido-1-methylbutyl)amino>-5--4-vinylquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 2N hydrochloric acid, stannous chloride, tin / tetrahydrofuran; ethanol / 1 h / 5 - 10 °C

2: triethylamine / dimethylformamide / 90 °C

With hydrogenchloride; tin; triethylamine; tin(ll) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00149a004