N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Base Information

Chemical Name:N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide
CAS No.:873326-25-1
Molecular Formula:C₄₆H₆₁N₅O₈
Molecular Weight:812.019
Hs Code.:

N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Synonyms:N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Suppliers and Price of N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

There total 18 articles about N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 873326-05-7
(2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoic acid

: 873326-32-0
L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

: 873326-25-1
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -20 - 23 ℃; for 8.5h;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-22-8
tert-butyl (3R)-3-amino-3-(4-methoxyphenyl)propanoate

: 873326-25-1
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / HOBt; DCC / tetrahydrofuran / 0 °C

2: 78 percent / Et₂NH / tetrahydrofuran / 1.33 h / 0 - 23 °C

3: 97 percent / HOBt; DCC / tetrahydrofuran / 12 h / 0 °C

4: 85 percent / Et₂NH / tetrahydrofuran / 1.33 h / 0 - 23 °C

5: 92 percent / DCC; HOBt / tetrahydrofuran / 8.5 h / -20 - 23 °C

With benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1002/chem.200500319

Reference yield:

: 3-isocyanato-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

: 873326-25-1
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-D-tryptophanamide

Guidance literature:: Multi-step reaction with 7 steps

1: 0.61 g / toluene / 3 h / Heating

2: 60 percent / Et₂NH / tetrahydrofuran / 12 h / 23 °C

3: 91 percent / HOBt; DCC / tetrahydrofuran / 0 °C

4: 78 percent / Et₂NH / tetrahydrofuran / 1.33 h / 0 - 23 °C

5: 97 percent / HOBt; DCC / tetrahydrofuran / 12 h / 0 °C

6: 85 percent / Et₂NH / tetrahydrofuran / 1.33 h / 0 - 23 °C

7: 92 percent / DCC; HOBt / tetrahydrofuran / 8.5 h / -20 - 23 °C

With benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene;
DOI:10.1002/chem.200500319