cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Base Information

Chemical Name:cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate
CAS No.:1209006-08-5
Molecular Formula:C₂₈H₃₉N₅O₄S
Molecular Weight:541.715
Hs Code.:

Synonyms:cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

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Chemical Property of cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

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Technology Process of cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

There total 7 articles about cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1209006-98-3
cyclohexyl 4-{4-[(2-amino-1-benzothiophen-3-yl)-carbonyl]piperazin-1-yl}piperidine-1-carboxylate

: 75-04-7,85404-22-4
ethylamine

: 1209006-08-5
cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; cyclohexyl 4-{4-[(2-amino-1-benzothiophen-3-yl)-carbonyl]piperazin-1-yl}piperidine-1-carboxylate; With triethylamine; In chloroform; at 0 ℃; for 0.0833333h;

ethylamine; In chloroform; water; at 20 ℃; for 0.166667h;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209006-78-9
tert-butyl 4-{4-[(2-amino-1-benzothiophen-3-yl)carbonyl]piperazin-1-yl}piperidine-1-carboxylate

: 1209006-08-5
cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 48 h

2.1: triethylamine / chloroform / 1 h / 0 °C

3.1: triethylamine / chloroform / 0.08 h / 0 °C

3.2: 0.17 h / 20 °C

With hydrogenchloride; triethylamine; In chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2011.01.041

Reference yield:

: 1209006-77-8
(2-amino-1-benzothiophen-3-yl)(piperazin-1-yl)methanone

: 1209006-08-5
cyclohexyl 4-[4-({2-[(ethylcarbamoyl)amino]-1-benzothiophen-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / chloroform / 16 h / 20 °C

2.1: hydrogenchloride / ethyl acetate / 48 h

3.1: triethylamine / chloroform / 1 h / 0 °C

4.1: triethylamine / chloroform / 0.08 h / 0 °C

4.2: 0.17 h / 20 °C

With hydrogenchloride; sodium tris(acetoxy)borohydride; triethylamine; In chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2011.01.041