4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃

Base Information

• Chemical Name: 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃
• CAS No.: 190834-04-9
• Molecular Formula: C₃₂H₃₇ClN₂O₇S₂
• Molecular Weight: 661.24

Synonyms:4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃

Chemical Property of 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃

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Technology Process of 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃

There total 2 articles about 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-[(4-Chlorophenyl)sulfonylaminocarbonyl] benzene carboxylic acid (105080-63-5) + S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH3 hydrochloride → 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH3 (190834-04-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jm960772z

Reference yield:

N-(tert-butoxycarbonyl)-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH3 (190834-02-7) → 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH3 (190834-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / HCl(gas.) / dioxane / Ambient temperature

2: 66 percent / BOP, DIEA / dimethylformamide / 18 h / Ambient temperature

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm960772z

Reference yield: 61.0%

4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH3 (190834-04-9) → 4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OH (190834-05-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 60 ℃; for 20h;

DOI:10.1021/jm960772z

upstream raw materials:

4-[(4-Chlorophenyl)sulfonylaminocarbonyl] benzene carboxylic acid

N-(tert-butoxycarbonyl)-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OCH₃

Downstream raw materials:

4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)benzoyl-S-(4-hydroxy-3,5-di-tert-butylphenyl)-Cys-OH

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