N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol

Base Information

• Chemical Name: N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol
• CAS No.: 169905-22-0
• Molecular Formula: C₂₂H₂₉NO₄
• Molecular Weight: 371.477
• Mol file: 169905-22-0.mol

Synonyms:N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol

Chemical Property of N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol

There total 8 articles about N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S)-2--3-phenyl-1-propanol (91373-74-9) → N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol (169905-22-0)

Guidance literature:

In 1,4-dioxane; for 18h; Ambient temperature;

DOI:10.1021/jo00129a057

Reference yield:

(2S)-methyl 2--3-phenyl-1-propanoate (59490-36-7) → N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol (169905-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄

2: 98 percent / dioxane

With lithium aluminium tetrahydride; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2005.02.166

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-(tert-Butoxycarbonyl)-N-(4-methoxybenzyl)-L-phenylalaninol (169905-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / LiAlH₄

2: 98 percent / dioxane

With lithium aluminium tetrahydride; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2005.02.166

upstream raw materials:

di-tert-butyl dicarbonate

(2S)-2--3-phenyl-1-propanol

(S)-2-[N-tert-butoxycarbonyl-N-(4′-Methoxybenzyl)amino]-3-phenylpropionaldehyde

(2S)-methyl 2--3-phenyl-1-propanoate

Downstream raw materials:

ethyl (4S,2E)-4-(4-methoxybenzylamino)-2-methyl-5-phenylpent-2-enoate

ethyl (4S,2Z)-4-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]-2-methyl-5-phenylpent-2-enoate

ethyl (4S,2E)-4-[tert-butoxycarbonyl-(4-methoxybenzyl)amino]-2-methyl-5-phenylpent-2-enoate

ethyl (2R)-2-[(3S,4S)-3-benzyl-2-(4-methoxybenzyl)-1-oxo-2-azaspiro[4.5]decan-4-yl]propanoate