4-(4-chlorophenyl)-1-piperazinopentanenitrile

Base Information

• Chemical Name: 4-(4-chlorophenyl)-1-piperazinopentanenitrile
• CAS No.: 258882-52-9
• Molecular Formula: C₁₅H₂₀ClN₃
• Molecular Weight: 277.797
• Mol file: 258882-52-9.mol

Synonyms:4-(4-chlorophenyl)-1-piperazinopentanenitrile

Chemical Property of 4-(4-chlorophenyl)-1-piperazinopentanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-chlorophenyl)-1-piperazinopentanenitrile

There total 1 articles about 4-(4-chlorophenyl)-1-piperazinopentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(4-chlorophenyl) piperazine (38212-33-8) + δ-chlorovaleronitrile (6280-87-1) → 4-(4-chlorophenyl)-1-piperazinopentanenitrile (258882-52-9)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1021/jm991138z

Reference yield: 100.0%

4-(4-chlorophenyl)-1-piperazinopentanenitrile (258882-52-9) → 4-(4-chlorophenyl)-1-piperazinepentanamine (258882-53-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jm991138z

Reference yield:

4-(4-chlorophenyl)-1-piperazinopentanenitrile (258882-52-9) → N-{5-[4-(4-chloro-phenyl)-piperazin-1-yl]-pentyl}-3-methoxy-benzamide

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / (CH₃)2S*BH₃ / tetrahydrofuran / 1 h / Heating

2: NaHCO₃ / CH₂Cl₂

With dimethylsulfide borane complex; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1021/jm991138z

upstream raw materials:

4-(4-chlorophenyl) piperazine

δ-chlorovaleronitrile

Downstream raw materials:

4-(4-chlorophenyl)-1-piperazinepentanamine