1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Base Information

Chemical Name:1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil
CAS No.:358625-48-6
Molecular Formula:C₅₂H₄₉N₅O₉
Molecular Weight:887.989
Hs Code.:

Synonyms:1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

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Chemical Property of 1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

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Technology Process of 1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

There total 7 articles about 1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 358625-44-2
1-[(2,4'-anhydro)-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

: 358625-48-6
1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 120 ℃; for 23h;
DOI:10.1021/jo015602v

Reference yield:

: Methanesulfonic acid (2R,3R,5S)-2,5-bis-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 358625-48-6
1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 70 ℃; for 48h;
DOI:10.1021/jo015602v

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 358625-48-6
1-[4'-azido-3'-deoxy-1',6'-di-O-(4,4'-dimethoxytrityl)-β-D-psicofuranosyl]uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

2: 93 percent / pyridine / 2 h / 0 °C

3: 80 percent / sodium hydride / dimethylformamide / 72 h / 20 °C

4: 26 percent / sodium azide / dimethylformamide / 23 h / 120 °C

With pyridine; sodium azide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo015602v