(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

Base Information

Chemical Name:(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one
CAS No.:177349-44-9
Molecular Formula:C₃₂H₄₂O₂Si
Molecular Weight:486.77
Hs Code.:

Synonyms:(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

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Chemical Property of (5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

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Technology Process of (5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

There total 1 articles about (5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 521-18-6
Stanolone

: 144-79-6
chloromethyldiphenylsilane

: 177349-44-9
(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

Guidance literature:: With 1H-imidazole; In dichloromethane; for 15h; Ambient temperature;
DOI:10.1021/ja960126p

Reference yield:

: 177349-44-9
(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

: Z-bis-5α-androstane-3,3'-ene-17β,17β'-diol bis(p-dimethylaminobenzoate)

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TiCl₃, LiAlH₄, 2.) TBAF / 1.) THF, reflux, 20 h, 2.) THF, RT, 3 h

2: 45 percent / DBU / CH₂Cl₂ / 24 h / Ambient temperature

With lithium aluminium tetrahydride; titanium(III) chloride; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1021/ja960126p

Reference yield:

: 177349-44-9
(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-(methyl-diphenyl-silanyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-one

: (Z)-(5S,8R,9S,10S,13S,14S,17S,5'S,8'R,9'S,10'S,13'S,14'S,17'S)-10,13,10',13'-Tetramethyl-17,17'-bis-(methyl-diphenyl-silanyloxy)-dotriacontahydro-[3,3']bi[cyclopenta[a]phenanthrenylidene]

: (E)-(5S,8R,9S,10S,13S,14S,17S,5'S,8'R,9'S,10'S,13'S,14'S,17'S)-10,13,10',13'-Tetramethyl-17,17'-bis-(methyl-diphenyl-silanyloxy)-dotriacontahydro-[3,3']bi[cyclopenta[a]phenanthrenylidene]

Guidance literature:: With lithium aluminium tetrahydride; titanium(III) chloride; In tetrahydrofuran; for 20h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
DOI:10.1021/ja960126p