N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

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Chemical Name:N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester
CAS No.:232615-14-4
Molecular Formula:C₃₂H₄₂N₄O₄
Molecular Weight:546.71
Hs Code.:

N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

Synonyms:N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

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Chemical Property of N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

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Technology Process of N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

There total 4 articles about N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R)-2-methylamino-3-phenylpropionic acid trimethylhydrazide dihydrochloride

: 147577-61-5
(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

: 232615-14-4
N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; 1-(3-N,N-dimethylaminopropyl)-3-ethylcarbodiimide; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1021/op0200118

Reference yield:

: 232615-12-2
N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamic acid tert-butyl ester

: 232615-14-4
N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.31 g / CF₃COOH / CH₂Cl₂ / 0.5 h

2.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 0.5 h

2.2: 0.43 g / iPr₂NEt / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; 1.1: solvolysis / 2.1: Addition / 2.2: Condensation;
DOI:10.1016/S0223-5234(00)00146-X

Reference yield:

: 37553-65-4,64263-83-8,85466-66-6
N-tert-butoxycarbonyl-N-methyl-D-phenylalanine

: 232615-14-4
N-methyl-N-((1R)-1-(N-methyl-N-[(1R)-2-phenyl-1-(N,N',N'-trimethylhydrazinocarbonyl)ethyl]carbamoyl)-2-(2-naphthyl)ethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / CH₂Cl₂ / 0.5 h

1.2: 0.30 g / iPr₂NEt / CH₂Cl₂ / 48 h

2.1: 0.31 g / CF₃COOH / CH₂Cl₂ / 0.5 h

3.1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl; 1-hydroxy-7-azabenzotriazole / CH₂Cl₂ / 0.5 h

3.2: 0.43 g / iPr₂NEt / CH₂Cl₂

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; 1.1: Addition / 1.2: Condensation / 2.1: solvolysis / 3.1: Addition / 3.2: Condensation;
DOI:10.1016/S0223-5234(00)00146-X