(S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid

Base Information

• Chemical Name: (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid
• CAS No.: 579469-90-2
• Molecular Formula: C₄₆H₆₅N₃O₁₂Si
• Molecular Weight: 880.12

Synonyms:(S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid

Chemical Property of (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid

There total 17 articles about (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester (579469-89-9) → (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid (579469-90-2)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(03)00856-6

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid (579469-90-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 99 percent / NaHCO₃ / dioxane; H₂O / 18 h / 25 °C

2.1: 78 percent / NaH / dimethylformamide; tetrahydrofuran / 72 h / 25 °C

3.1: 82 percent / EtOCOCl; NaBH₄ / tetrahydrofuran; methanol / 0.33 h / 0 °C

4.1: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 8 h / 25 °C

5.1: 99 percent / i-PrMgCl; t-BuLi; (MeO)3B / tetrahydrofuran / 1 h / -78 - 25 °C

6.1: 95 percent / Na₂CO₃; (o-tolyl)3P / Pd₂(dba)3 / toluene; methanol / 0.25 h / 85 °C

7.1: 99 percent / H₂ / Pd/C / methanol / 15 h / 25 °C / 760 Torr

8.1: 93 percent / EDCI; HOAt / dimethylformamide

9.1: HCl / ethyl acetate / 0.5 h / -10 °C

9.2: 69 percent / NaHCO₃ / tetrahydrofuran; H₂O

10.1: 55 percent / Jones reagent / acetone / 1 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; jones reagent; Trimethyl borate; hydrogen; tert.-butyl lithium; isopropylmagnesium chloride; chloroformic acid ethyl ester; sodium hydride; sodium hydrogencarbonate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 10.1: Jones oxidation;

DOI:10.1016/S0040-4039(03)00856-6

Reference yield:

3-Iodo-L-tyrosine (70-78-0) → (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid (579469-90-2)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 99 percent / NaHCO₃ / dioxane; H₂O / 18 h / 25 °C

2.1: 78 percent / NaH / dimethylformamide; tetrahydrofuran / 72 h / 25 °C

3.1: 82 percent / EtOCOCl; NaBH₄ / tetrahydrofuran; methanol / 0.33 h / 0 °C

4.1: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 8 h / 25 °C

5.1: 99 percent / i-PrMgCl; t-BuLi; (MeO)3B / tetrahydrofuran / 1 h / -78 - 25 °C

6.1: 95 percent / Na₂CO₃; (o-tolyl)3P / Pd₂(dba)3 / toluene; methanol / 0.25 h / 85 °C

7.1: 99 percent / H₂ / Pd/C / methanol / 15 h / 25 °C / 760 Torr

8.1: 93 percent / EDCI; HOAt / dimethylformamide

9.1: HCl / ethyl acetate / 0.5 h / -10 °C

9.2: 69 percent / NaHCO₃ / tetrahydrofuran; H₂O

10.1: 55 percent / Jones reagent / acetone / 1 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; jones reagent; Trimethyl borate; hydrogen; tert.-butyl lithium; isopropylmagnesium chloride; chloroformic acid ethyl ester; sodium hydride; sodium hydrogencarbonate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 10.1: Jones oxidation;

DOI:10.1016/S0040-4039(03)00856-6

upstream raw materials:

(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester

di-tert-butyl dicarbonate

3-Iodo-L-tyrosine

L-3-(3-acetyl-4-hydroxyphenyl)-N-(benzyloxycarbonyl)alanine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 579469-90-2 (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send