(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

Base Information

Chemical Name:(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide
CAS No.:1345691-67-9
Molecular Formula:C₁₈H₁₇ClN₂O₄S
Molecular Weight:392.863
Hs Code.:

Synonyms:(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

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Chemical Property of (-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

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Technology Process of (-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

There total 4 articles about (-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1020104-34-0
N-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-(R)-yl)-4-(4-chloro-phenoxy)-benzenesulfonamide

: 1345691-67-9
(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

Guidance literature:: With samarium diiodide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-29-3
(+)-[1-(allyl-benzyloxy-carbamoyl)-but-3-(R)-enyl]-carbamic acid tert-butyl ester

: 1345691-67-9
(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: pyridine / dichloromethane / 120 h / 20 °C

4: samarium diiodide / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; samarium diiodide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-31-7
(-)-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-R-yl)-carbamic acid tert-butyl ester

: 1345691-67-9
(-)-4-(4-chloro-phenoxy)-N-(2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: pyridine / dichloromethane / 120 h / 20 °C

3: samarium diiodide / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; samarium diiodide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.068