(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate
CAS No.:1609545-78-9
Molecular Formula:C₂₄H₃₃FNO₆P
Molecular Weight:481.501
Hs Code.:

Synonyms:(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

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Chemical Property of (R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

Chemical Property:

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Technology Process of (R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

There total 4 articles about (R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1609534-68-0
(R)-tert-butyl (2-fluoro-3-hydroxy-3-methylbutyl)carbamate

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1609545-78-9
(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

Guidance literature:: (R)-tert-butyl (2-fluoro-3-hydroxy-3-methylbutyl)carbamate; Dibenzyl N,N-diisopropylphosphoramidite; With 1H-tetrazole; In dichloromethane; at 20 ℃; for 1h;

With dihydrogen peroxide; In dichloromethane; for 1h;

Reference yield:

: 1544241-64-6
(3R)-4-amino-3-fluoro-2-methylbutan-2-ol

: 1609545-78-9
(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 20 °C

2.1: 1H-tetrazole / dichloromethane / 1 h / 20 °C

2.2: 1 h

With 1H-tetrazole; triethylamine; In dichloromethane;

Reference yield:

: 1609545-83-6,2108176-83-4
(R)-4-(dibenzylamino)-3-fluoro-2-methylbutan-2-ol

: 1609545-78-9
(R)-tert-butyl (3-((bis(benzyloxy)phosphoryl)oxy)-2-fluoro-3-methylbutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium(II) hydroxide; hydrogen; palladium on activated charcoal / methanol / 18 h

2.1: triethylamine / dichloromethane / 20 °C

3.1: 1H-tetrazole / dichloromethane / 1 h / 20 °C

3.2: 1 h

With 1H-tetrazole; palladium on activated charcoal; hydrogen; palladium(II) hydroxide; triethylamine; In methanol; dichloromethane;