(E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide

Base Information

• Chemical Name: (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide
• CAS No.: 192642-97-0
• Molecular Formula: C₁₃H₁₂BrN₃O₂S
• Molecular Weight: 354.227
• Mol file: 192642-97-0.mol

Synonyms:(E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide

Chemical Property of (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide

There total 4 articles about (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-pyridine-2-carbaldehyde (31181-90-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide (192642-97-0)

Guidance literature:

In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield:

(5-bromopyridin-2-yl)methanol (88139-91-7) → (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide (192642-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

2: 87 percent

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(97)00491-2

Reference yield:

(5-bromopyridin-2-yl)methyl acetate (31181-74-5) → (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide (192642-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / aq. HCl / Heating

2: 75 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

3: 87 percent

With hydrogenchloride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(97)00491-2

upstream raw materials:

5-bromo-pyridine-2-carbaldehyde

toluene-4-sulfonic acid hydrazide

(5-bromopyridin-2-yl)methanol

(5-bromopyridin-2-yl)methyl acetate

Downstream raw materials:

6-bromo-[1,2,3]triazolo[1,5-a]pyridine