1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine

Base Information

• Chemical Name: 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine
• CAS No.: 1422064-40-1
• Molecular Formula: C₂₃H₃₀N₄O₆
• Molecular Weight: 458.514
• Mol file: 1422064-40-1.mol

Synonyms:1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine

Chemical Property of 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine

There total 9 articles about 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-3-trityl-L-histidinate (1422064-37-6) → triphenylmethane (519-73-3) + 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine (1422064-40-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 760.051 Torr;

DOI:10.3390/molecules18010050

Reference yield:

[4-(4-methoxybutoxy)phenyl]methanol (1422064-25-2) → 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine (1422064-40-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium bromide; chloro-trimethyl-silane / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; paraffin oil / 24.25 h / 0 - 20 °C / Inert atmosphere

3: sodium hydroxide; water / methanol / 20 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 19 h / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With chloro-trimethyl-silane; palladium 10% on activated carbon; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bromide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; paraffin oil;

DOI:10.3390/molecules18010050

Reference yield:

methyl 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolinate (1422064-31-0) → 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolyl-L-histidine (1422064-40-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol / 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 19 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 760.05 Torr

With palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; dichloromethane;

DOI:10.3390/molecules18010050

upstream raw materials:

[4-(4-methoxybutoxy)phenyl]methanol

methyl 1-[4-(4-methoxybutoxy)benzyl]-5-oxo-L-prolinate

4-Methoxy-1-bromobutane

1-(bromomethyl)-4-(4-methoxybutoxy)benzene