3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

Base Information

Chemical Name:3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine
CAS No.:886584-63-0
Molecular Formula:C₂₆H₂₇N₃O₂
Molecular Weight:413.519
Hs Code.:

Synonyms:3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

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Chemical Property of 3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

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Technology Process of 3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

There total 5 articles about 3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 870-64-4
2-aminocrotononitrile

: 4-dimethylamino-4'-(tetrahydro-2H-pyran-2-yloxy)chalcone

: 886584-63-0
3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

Guidance literature:: With sodium hydroxide; In ethanol;

Reference yield: 44.0%

: 1118-61-2
3-Aminocrotononitrile

: 886584-62-9
4-dimethylamino-4'-(tetrahydro-2H-pyran-2-yloxy)chalcone

: 886584-63-0
3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

Guidance literature:: 3-Aminocrotononitrile; 4-dimethylamino-4'-(tetrahydro-2H-pyran-2-yloxy)chalcone; With sodium hydroxide; In ethanol; for 29h; Heating;

With oxygen; In ethanol; at 20 ℃; for 12h;
DOI:10.1021/ol0602708

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 886584-63-0
3-cyano-4-(4-dimethylaminophenyl)-6-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-2-methylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: p-toluenesulfonic acid / CH₂Cl₂ / 17 h / 20 °C

2.1: 78 percent / NaOH / ethanol; H₂O / 18 h / 20 °C

3.1: sodium hydroxide / ethanol / 29 h / Heating

3.2: 44 percent / oxygen / ethanol / 12 h / 20 °C

With sodium hydroxide; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; 2.1: Claisen-Schmidt condensation;
DOI:10.1021/ol0602708