Technology Process of (R)-3-(2,3-dimethoxy-4-methylphenyl)butanoic acid
There total 10 articles about (R)-3-(2,3-dimethoxy-4-methylphenyl)butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water; diethylene glycol;
for 2h;
Reflux;
DOI:10.1002/ejoc.201200620
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydroquinone / benzene / Reflux
2.1: dimethyl sulfide borane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2.2: 1 h / 40 °C / Inert atmosphere
3.1: sodium hydroxide / methanol / 1 h / Reflux; Enzymatic reaction
3.2: 20 °C
4.1: sodium hydroxide / methanol / Reflux
5.1: pyridine / dichloromethane / 4 h
6.1: dimethyl sulfoxide / 3 h / 80 - 90 °C
7.1: sodium hydroxide / water; diethylene glycol / 2 h / Reflux
With
pyridine; dimethyl sulfide borane; hydroquinone; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; diethylene glycol; benzene;
DOI:10.1002/ejoc.201200620
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere
2.1: hydroquinone / benzene / Reflux
3.1: dimethyl sulfide borane / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3.2: 1 h / 40 °C / Inert atmosphere
4.1: sodium hydroxide / methanol / 1 h / Reflux; Enzymatic reaction
4.2: 20 °C
5.1: sodium hydroxide / methanol / Reflux
6.1: pyridine / dichloromethane / 4 h
7.1: dimethyl sulfoxide / 3 h / 80 - 90 °C
8.1: sodium hydroxide / water; diethylene glycol / 2 h / Reflux
With
pyridine; dimethyl sulfide borane; hydroquinone; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; diethylene glycol; benzene;
DOI:10.1002/ejoc.201200620
