2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

Base Information

Chemical Name:2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide
CAS No.:1366000-19-2
Molecular Formula:C₁₆H₁₅IN₄O₃
Molecular Weight:438.225
Hs Code.:

Synonyms:2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

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Chemical Property of 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

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Technology Process of 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

There total 7 articles about 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₄N₆O₄

: 626-01-7
3-Iodoaniline

: 1366000-19-2
2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2012.01.020

Reference yield:

: 55326-07-3
1,3,6-trimethyl-5-nitrouracil

: 1366000-19-2
2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 4 h / 120 °C

2: acetic acid; zinc / 0.5 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: sodium hydroxide / methanol / 2 h / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

6: N,N-dimethyl-formamide / 20 °C

With potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.020

Reference yield:

: 1366000-13-6
(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-acetic acid ethyl ester

: 1366000-19-2
2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / methanol / 2 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

3: N,N-dimethyl-formamide / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.020