[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

Base Information

Chemical Name:[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid
CAS No.:923580-09-0
Molecular Formula:C₂₁H₁₇ClFNO₄S
Molecular Weight:433.888
Hs Code.:

Synonyms:[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

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Technology Process of [4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

There total 1 articles about [4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.6%

: 866215-99-8
[4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1,4-dihydro-2H-cyclopenta[b]indol-3-ylidene]-acetic acid

: 923580-09-0
[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

Guidance literature:: With N,N,N',N'-tetramethylguanidine; [(S-BINAP)Ru(p-cymene)Cl₂]2; In methanol; at 50 ℃; for 3h;
DOI:10.1021/ja0623358

Reference yield:

: 923580-09-0
[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: C₂₁H₁₇⁽²⁾H₂ClFNO₄S*C₅H₁₃N₃

Guidance literature:: With deuterium; [(S-BINAP)Ru(p-cymene)Cl₂]2; In methanol; at 50 ℃; for 2h; under 1292.87 Torr;
DOI:10.1021/ja0623358

Reference yield:

: 923580-09-0
[4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,4-dihydrocyclopenta[b]indol-3-yl]acetic acid

: 80-70-6
N,N,N',N'-tetramethylguanidine

: [4-(4-chloro-benzyl)-7-fluoro-5-methanesulfonyl-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]-acetic acid; compound with N,N,N',N'-tetramethyl-guanidine

: [(3R)-4-(4-chlorophenyl)methyl-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl]acetic acid, TMG salt

Guidance literature:: With hydrogen; Ru(S-BINAP)(OAc)2; In d⁽⁴⁾-methanol; at 50 ℃; under 1292.87 Torr; Title compound not separated from byproducts;
DOI:10.1021/ja0623358