(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

Base Information

Chemical Name:(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester
CAS No.:135673-28-8
Molecular Formula:C₂₉H₄₅NO₇
Molecular Weight:519.679
Hs Code.:

Synonyms:(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

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Chemical Property of (2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

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Technology Process of (2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

There total 2 articles about (2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 20781-21-9
2,4-dimethoxybenzylamine hydrochloride

: 112830-96-3
(2'R,3'R,7R)-(E,E)-methyl 11-<3'-(hydroxymethyl)-4'-oxo-2'-oxethanyl>-3,5,7-trimethyl-2,4-undecadienoate

: 135673-28-8
(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

Guidance literature:: With triethylamine; In water; at 22 ℃; for 1h;
DOI:10.1016/S0040-4039(00)92700-X

Reference yield:

: 34668-59-2,112965-15-8,113774-42-8
(7R,2'R,3'R)-11-<3'-(hydroxymethyl)-4'-oxo-2'-oxetanoyl>-3,5,7-trimethyl-2,4-undecadienoic acid methyl ester

: 135673-28-8
(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / Ag₂O / 5 h / 47 °C

2: 50 percent / Et₃N / H₂O / 1 h / 22 °C

With triethylamine; silver(l) oxide; In water;
DOI:10.1016/S0040-4039(00)92700-X

Reference yield:

: 135673-28-8
(2E,4E)-(7R,12R,13R)-13-(2,4-Dimethoxy-benzylcarbamoyl)-12-hydroxy-14-methoxy-3,5,7-trimethyl-tetradeca-2,4-dienoic acid methyl ester

: 135700-29-7
(2E,4E)-(R)-11-[(2R,3S)-3-Methoxymethyl-4-oxo-1-(toluene-4-sulfonyl)-azetidin-2-yl]-3,5,7-trimethyl-undeca-2,4-dienoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridine / 2 h / 0 °C

2: NaBr / dimethylformamide / 1 h / 100 °C

3: 53 percent / KOH, n-Bu₄NBr / acetonitrile; CH₂Cl₂ / 16 h / 22 °C

4: 65 percent / (NH₄)2Ce(NO₃)6 / tetrahydrofuran; H₂O / 1.5 h / 22 °C

5: KOH, n-Bu₄NBr

With pyridine; potassium hydroxide; ammonium cerium(IV) nitrate; tetrabutylammomium bromide; sodium bromide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)92700-X