(1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide

Base Information

• Chemical Name: (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide
• CAS No.: 1159633-62-1
• Molecular Formula: C₂₀H₂₄NOP
• Molecular Weight: 325.39
• Mol file: 1159633-62-1.mol

Synonyms:(1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide

Chemical Property of (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide

There total 3 articles about (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

diethylphosphoramidous dichloride (1069-08-5) + 1,4-diphenyl-1,3-butadiene → (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide (1159633-62-1)

Guidance literature:

diethylphosphoramidous dichloride; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 0.75h; Inert atmosphere;

1,4-diphenyl-1,3-butadiene; In dichloromethane; at 0 ℃;

With nitrilotriacetic acid; water; sodium hydrogencarbonate; In dichloromethane; at 0 ℃; for 4h;

DOI:10.1002/adsc.200800226

Reference yield:

diethylphosphoramidous dichloride (1069-08-5) + trans,trans-1,4-Diphenyl-1,3-butadiene (886-65-7,538-81-8) → (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide (1159633-62-1) + (1R,2R,5S)-1-(diethylamino)-1-oxo-2,5-diphenyl-2,5-dihydro-1H-phosphole (1428334-56-8)

Guidance literature:

diethylphosphoramidous dichloride; trans,trans-1,4-Diphenyl-1,3-butadiene; With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

With nitrilotriacetic acid; sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 4h; Overall yield = 83 %; Overall yield = 12.3 g; Inert atmosphere;

DOI:10.1055/s-0032-1316835

Reference yield:

diethylphosphoramidous dichloride (1069-08-5) + trans,trans-1,4-Diphenyl-1,3-butadiene (886-65-7,538-81-8) → (1s,2R,5S)-1-(diethylamino)-2,5-diphenyl-2,5-dihydro-1H-phosphole 1-oxide (1159633-62-1)

Guidance literature:

With aluminum (III) chloride;

DOI:10.1055/s-0032-1318156

upstream raw materials:

diethylphosphoramidous dichloride

trans,trans-1,4-Diphenyl-1,3-butadiene

Downstream raw materials:

(1R,5R)-1-diethylamino-1-oxo-2,5-diphenyl-4,5-dihydro-1H-phosphole

(R,R)-(+)-1-hydroxy-1-oxo-2,5-trans-diphenylphospholane

1-hydroxy-cis-2,5-diphenyl-1λ⁵-phospholan-1-one

meso-1-hydroxy-1-oxo-2,5-diphenyl-2,5-dihydro-1H-phosphole