(R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide>

Base Information

• Chemical Name: (R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide>
• CAS No.: 127445-51-6
• Molecular Formula: C₃₀H₂₀F₁₂N₂O₄S₂
• Molecular Weight: 764.613
• Mol file: 127445-51-6.mol

Synonyms:(R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide>

Chemical Property of (R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide>

There total 1 articles about (R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-Bis-(trifluoromethyl)aniline (328-74-5) → (R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide> (127445-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. sodium nitrite, hydrochloric acid, 2.) sulfur dioxide, cupric chloride / 1.) AcOH, 0 deg C

2: 90 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With hydrogenchloride; dmap; sulfur dioxide; triethylamine; copper dichloride; sodium nitrite; In dichloromethane;

DOI:10.1021/ja00168a062

Reference yield:

(R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide> (127445-51-6) → (SO2C6H3(CF3)2NCHC6H5)2BCCH2CHCH2

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide

2: dichloromethane / 0 - 25 °C

With boron tribromide; In dichloromethane;

DOI:10.1039/c0cc05751g

Reference yield:

(R,R)-(+)-bis<3,5-bis(trifluoromethyl)benzenesulfonamide> (127445-51-6) → (4S,5S)-1,3-bis[(3,5-bis(trifluoromethyl)phenyl)sulfonyl]-2-bromo-4,5-diphenyl-1,3,2-diazaborolidine (133908-39-1)

Guidance literature:

With boron tribromide;

DOI:10.1039/c0cc05751g

upstream raw materials:

3,5-Bis-(trifluoromethyl)aniline

Downstream raw materials:

(4S,5S)-1,3-bis[(3,5-bis(trifluoromethyl)phenyl)sulfonyl]-2-bromo-4,5-diphenyl-1,3,2-diazaborolidine