(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Base Information

Chemical Name:(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide
CAS No.:110613-50-8
Molecular Formula:C₃₅H₅₂N₆O₅
Molecular Weight:636.835
Hs Code.:

(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Synonyms:(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Chemical Property:

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Technology Process of (4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

There total 4 articles about (4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118233-48-0
TBA-Phe-His-OH

: (4S,5S)-5-Amino-6-cyclohexyl-4-hydroxy-2-methylene-hexanoic acid methylamide; hydrochloride

: 110613-50-8
(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at -23 - 20 ℃;
DOI:10.1021/jm00394a008

Reference yield:

: 3887-02-3
N-methyl methacrylamide

: 110613-50-8
(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: HCl(g) / dioxane / 1 h / Ambient temperature

3: 1-hydroxybenzotriazole*H₂O, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide*HCl / dimethylformamide / -23 - 20 °C

With 4-methyl-morpholine; triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 110613-50-8
(4S,5S)-6-Cyclohexyl-5-[(S)-2-[(S)-2-(3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-4-hydroxy-2-methylene-hexanoic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: HCl(g) / dioxane / 1 h / Ambient temperature

3: 1-hydroxybenzotriazole*H₂O, 4-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide*HCl / dimethylformamide / -23 - 20 °C

With 4-methyl-morpholine; triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008