Technology Process of methyl (4S,5S,6R)-4,5,6-tris(benzyloxy)-7-hydroxy-2-(methoxycarbonyl)heptanoate
There total 9 articles about methyl (4S,5S,6R)-4,5,6-tris(benzyloxy)-7-hydroxy-2-(methoxycarbonyl)heptanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 2.5h;
Ambient temperature;
DOI:10.1021/jo00386a011
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaH / dimethylformamide
2: TsOH / methanol; ethyl acetate
3: imidazole / dimethylformamide
4: mercury(II)chloride / acetonitrile; H2O
5: 85 percent / acetic anhydride / pyridine / 48 h / Ambient temperature
6: H2 / Raney nickel
7: tetrabutylammonium fluoride
With
1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; sodium hydride; toluene-4-sulfonic acid; mercury dichloride;
nickel;
In
pyridine; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/cl.1986.1081
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DMAP / pyridine
2: NaH / dimethylformamide
3: TsOH / methanol; ethyl acetate
4: imidazole / dimethylformamide
5: mercury(II)chloride / acetonitrile; H2O
6: 85 percent / acetic anhydride / pyridine / 48 h / Ambient temperature
7: H2 / Raney nickel
8: tetrabutylammonium fluoride
With
1H-imidazole; dmap; tetrabutyl ammonium fluoride; hydrogen; acetic anhydride; sodium hydride; toluene-4-sulfonic acid; mercury dichloride;
nickel;
In
pyridine; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1246/cl.1986.1081
