7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

Base Information

Chemical Name:7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III
CAS No.:1411664-02-2
Molecular Formula:C₅₃H₆₃NO₁₂Si
Molecular Weight:934.168
Hs Code.:

Synonyms:7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

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Chemical Property of 7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

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Technology Process of 7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

There total 6 articles about 7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1411663-99-4
7-triethylsilyl-1-deoxybaccatin III

: 158722-22-6
(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

: 1411664-02-2
7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 50 ℃;
DOI:10.2174/157340612802084379

Reference yield:

: 1β-dehydroxybaccatine VI

: 1411664-02-2
7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

Guidance literature:: Multi-step reaction with 8 steps

1: N-benzyl-trimethylammonium hydroxide / dichloromethane / 2 h / 20 °C

2: cerium(III) chloride heptahydrate / tetrahydrofuran / 3 h / 40 °C

3: dmap / tetrahydrofuran / 0.33 h / 0 °C

4: tetrapropylammonium perruthennate / dichloromethane / 4 h / 20 °C

5: hydrazine hydrate / ethanol / 4 h / 20 °C

6: cerium(III) chloride heptahydrate / tetrahydrofuran / 0.5 h / 40 °C

7: 1H-imidazole / dichloromethane / 0.08 h / 20 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / toluene / 50 °C

With 1H-imidazole; dmap; tetrapropylammonium perruthennate; cerium(III) chloride heptahydrate; N-benzyl-trimethylammonium hydroxide; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.2174/157340612802084379

Reference yield:

: 132302-29-5
1-dehydroxylbaccatin III

: 1411664-02-2
7-triethylsilyl-13-[(5R)-2,4-diphenyl-2,5-dihydrooxazole-5-carboxylic]-1-deoxybaccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 0.08 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / toluene / 50 °C

With 1H-imidazole; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; toluene;
DOI:10.2174/157340612802084379