2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

Base Information

Chemical Name:2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol
CAS No.:1620017-13-1
Molecular Formula:C₂₆H₃₁BrO₃Si
Molecular Weight:499.52
Hs Code.:

Synonyms:2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

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Chemical Property of 2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

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Technology Process of 2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

There total 3 articles about 2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1620017-12-0
diethyl 2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]malonate

: 1620017-13-1
2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.06.024

Reference yield:

: 93139-85-6
2-(4-bromophenyl)malonic acid diethyl ester

: 1620017-13-1
2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; ethanol / 20 h / 0 - 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium borohydride; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.06.024

Reference yield:

: 1620017-11-9
diethyl 2-(4-bromophenyl)-2-(hydroxymethyl)malonate

: 1620017-13-1
2-(4-bromophenyl)-2-[(tert-butyldiphenylsilyloxy)methyl]propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2014.06.024 DOI:10.1016/j.tetlet.2014.06.024