diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate
CAS No.:124656-59-3
Molecular Formula:C₂₄H₃₃N₅O₆
Molecular Weight:487.556
Hs Code.:

Synonyms:diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

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Technology Process of diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

There total 8 articles about diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 125402-87-1
4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoic acid

: 51766-21-3
Phenyl N-phenylphosphoramidochloridate

: 124656-59-3
diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

Guidance literature:: With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; In methanol; chloroform;

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 124656-59-3
diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1: 75.8 percent / triphenylphosphine, diethylamine, copper(I) iodide / palladium chloride / 18 h / Ambient temperature

2: 2.60 g / H₂ / 5percent palladium-on-charcoal / ethanol / 12 h / 2585.7 Torr

3: triethylamine / diethyl ether / 4 h / 0 - 20 °C

4: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h

5: 1.) sodium methoxide / 1.) anhydrous methanol, nitrogen atmosphere, 0.5 h, 2.) anhydrous dimethylformamide, mild warming, 12 h

6: 71.3 percent / 1N sodium hydroxide / 18 h / Ambient temperature

7: 1.) phenyl N-phenylphosphoramidochloridate, N-methylmorpholine / 1.) anhydrous N-methylpyrrolidone, room temperature, 1 h, 2.) 24 h

With 4-methyl-morpholine; sodium hydroxide; copper(l) iodide; hydrogen; sodium methylate; sodium hydride; diethylamine; triethylamine; triphenylphosphine; Phenyl N-phenylphosphoramidochloridate; palladium on activated charcoal; palladium dichloride; In diethyl ether; ethanol;

Reference yield:

: 123910-86-1
4-(4-hydroxybut-1-ynyl)benzoic acid methyl ester

: 124656-59-3
diethyl N-<4-<4-(2,4-diamino-6(1H)-oxopyrimidin-5-yl)butyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 2.60 g / H₂ / 5percent palladium-on-charcoal / ethanol / 12 h / 2585.7 Torr

2: triethylamine / diethyl ether / 4 h / 0 - 20 °C

3: 1.) NaH / 1.) THF, 0 deg C -> room temperature, 2.) room temperature, 12 h; reflux, 6 h

4: 1.) sodium methoxide / 1.) anhydrous methanol, nitrogen atmosphere, 0.5 h, 2.) anhydrous dimethylformamide, mild warming, 12 h

5: 71.3 percent / 1N sodium hydroxide / 18 h / Ambient temperature

6: 1.) phenyl N-phenylphosphoramidochloridate, N-methylmorpholine / 1.) anhydrous N-methylpyrrolidone, room temperature, 1 h, 2.) 24 h

With 4-methyl-morpholine; sodium hydroxide; hydrogen; sodium methylate; sodium hydride; triethylamine; Phenyl N-phenylphosphoramidochloridate; palladium on activated charcoal; In diethyl ether; ethanol;