N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine

Base Information

• Chemical Name: N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine
• CAS No.: 1329429-89-1
• Molecular Formula: C₂₁H₁₉N₃O₂S
• Molecular Weight: 377.467
• Mol file: 1329429-89-1.mol

Synonyms:N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine

Chemical Property of N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine

There total 2 articles about N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3-(4-nitrophenyl)-1,1-dimethyl-thiourea (16349-44-3) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 1,1-dimethyl-3-(4-nitrophenyl)-2-phenyl-isothiourea (1329429-90-4) + N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine (1329429-89-1)

Guidance literature:

With cesium fluoride; In toluene; acetonitrile; at 90 ℃; Inert atmosphere;

DOI:10.1021/ol202049v

Reference yield:

p-nitrophenyl isothiocyanate (2131-61-5) → 1,1-dimethyl-3-(4-nitrophenyl)-2-phenyl-isothiourea (1329429-90-4) + N,N-dimethyl-N'-(4-nitrophenyl)-2-phenylsulfanyl-benzamidine (1329429-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C / Inert atmosphere

2: cesium fluoride / toluene; acetonitrile / 90 °C / Inert atmosphere

With cesium fluoride; In tetrahydrofuran; toluene; acetonitrile;

DOI:10.1021/ol202049v

upstream raw materials:

3-(4-nitrophenyl)-1,1-dimethyl-thiourea

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

p-nitrophenyl isothiocyanate