2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Base Information

Chemical Name:2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
CAS No.:1215119-31-5
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Chemical Property of 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Technology Process of 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

There total 10 articles about 2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215118-20-9
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1215119-30-4
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1215119-31-5
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: With ChiralPak AD-H; In ipa; carbon dioxide; at 25 ℃; under 75007.5 - 202520 Torr; Resolution of racemate;

Reference yield:

: 16732-70-0
ethyl 5-bromoindolecarboxylate

: 1215119-30-4
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1215119-31-5
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / toluene; mineral oil / 110 °C

1.2: 48 h / 110 °C

1.3: 16 h / Reflux

2.1: tetrahydrofuran / 16 h / 65 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

4.1: sodium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 0.42 h / 23 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr

6.1: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

7.1: trifluoroacetic acid; rac-cysteine / 0.25 h / 20 °C

8.1: ChiralPak AD-H / carbon dioxide; ipa / 25 °C / 75007.5 - 202520 Torr / Resolution of racemate

With rac-cysteine; hydrogen; dihydrogen peroxide; potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ipa; carbon dioxide; water; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1215119-77-9
tert-butyl 2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ylidene)acetate

: 1215119-30-4
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

: 1215119-31-5
2-(7-(3-cyano-4-isopropoxybenzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate; water / 3 h / 4913.04 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C

3: trifluoroacetic acid; rac-cysteine / 0.25 h / 20 °C

4: ChiralPak AD-H / carbon dioxide; ipa / 25 °C / 75007.5 - 202520 Torr / Resolution of racemate

With rac-cysteine; hydrogen; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In ipa; carbon dioxide; water; ethyl acetate; N,N-dimethyl-formamide;