1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

Base Information

Chemical Name:1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester
CAS No.:1430840-23-5
Molecular Formula:C₂₅H₂₄N₄O₃
Molecular Weight:428.491
Hs Code.:

Synonyms:1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

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Chemical Property of 1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

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Technology Process of 1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

There total 6 articles about 1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1430841-51-2
C₂₇H₂₈N₄O₃

: 1430840-23-5
1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: With hydrogenchloride; In methanol; water; at 50 ℃; for 16h;

Reference yield:

: C₁₈H₁₇N₃O₃

: 1430840-23-5
1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / toluene / 50 °C / Inert atmosphere

2: hydrogenchloride / methanol; water / 16 h / 50 °C

With hydrogenchloride; trifluoroacetic acid; In methanol; water; toluene;

Reference yield:

: 1430841-32-9
tert-butyl 5-(benzamidomethyl)-6-methoxypyrazin-2-ylcarbamate

: 1430840-23-5
1-benzyl-4-(8-oxo-3-phenyl-7,8-dihydroimidazo[1,5-a]pyrazin-6-yl)-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: copper(l) iodide; isopentyl nitrite; diiodomethane / tetrahydrofuran / 5 h / 75 °C / Inert atmosphere

3: trichlorophosphate / acetonitrile / 6 h / 85 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate / 1,4-dioxane / 48 h / 75 °C / Inert atmosphere

5: trifluoroacetic acid / toluene / 50 °C / Inert atmosphere

6: hydrogenchloride / methanol; water / 16 h / 50 °C

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; diiodomethane; potassium carbonate; trifluoroacetic acid; trichlorophosphate; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;