Eflornithine hydrochloride hydrate

Base Information

• Chemical Name: Eflornithine hydrochloride hydrate
• CAS No.: 96020-91-6
• Molecular Formula: C6H12F2N2O2^.HCl^.H2O
• Molecular Weight: 236.65
• Hs Code.: 2922493800
• European Community (EC) Number: 619-187-0
• UNII: 4NH22NDW9H
• DSSTox Substance ID: DTXSID4045765
• Wikidata: Q27260247
• NCI Thesaurus Code: C1579
• RXCUI: 81945
• ChEMBL ID: CHEMBL1201037
• Mol file: 96020-91-6.mol

Synonyms:DL-Ornithine,2-(difluoromethyl)-, monohydrochloride, monohydrate;Ornithine, 2-(difluoromethyl)-,monohydrochloride, monohydrate (9CI);Eflornithine HCl;

Chemical Property of Eflornithine hydrochloride hydrate

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: >210 °C (dec.)
• Boiling Point: 347 °C at 760 mmHg
• Flash Point: 163.7 °C
• PSA: 98.57000
• Density: 1.293g/cm3
• LogP: 1.91080
• Storage Temp.: -20°C Freezer
• Solubility.: Soluble in Water (up to 25 mg/ml).
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 236.0739264
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

98%,99%, ^*data from raw suppliers

Eflornithine Hydrochloride Monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(C(F)F)(C(=O)O)N)CN.O.Cl
• Recent ClinicalTrials: TArgeting Type 1 Diabetes Using POLyamines (TADPOL)
• Recent EU Clinical Trials: A Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
• Description: Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.
• Uses: Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.