1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

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Chemical Name:1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine
CAS No.:1457967-08-6
Molecular Formula:C₂₅H₂₅F₃N₄O
Molecular Weight:454.495
Hs Code.:

Synonyms:1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

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Technology Process of 1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

There total 8 articles about 1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1457967-44-0
C₃₃H₄₁F₃N₄O

: 1457967-08-6
1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1039/c3ob40816g

Reference yield: 47.0%

: 1457967-08-6
1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

: 2587-03-3
2,6-dichloro-N-nitro-4-pyridinamine

: 1457967-08-6
1-benzyl-2-butyl-6-(4-(trifluoromethoxy)benzyl)-1H-imidazo[4,5-c]pyridin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 0.5 h / 90 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: triethylamine / dichloromethane / 48 h / Reflux

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / water; 1,4-dioxane / 18 h / 90 °C / Inert atmosphere; Sealed tube

5.1: zinc; ammonium formate / methanol / 0.17 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 1 h / Reflux

7.1: sodium hydroxide / ethanol; water / 18 h / Reflux

8.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; ammonium formate; sodium hydride; caesium carbonate; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 4.1: |Suzuki Coupling;
DOI:10.1039/c3ob40816g