N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Base Information

Chemical Name:N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide
CAS No.:937018-48-9
Molecular Formula:C₃₃H₃₈N₈O₄
Molecular Weight:610.716
Hs Code.:

Synonyms:N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

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Chemical Property of N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

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Technology Process of N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

There total 8 articles about N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 929899-51-4
N-[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]-N-ethylethan-1,2-diamine

: 19234-66-3
2',3'-isopropylideneadenosine-5'-carboxylic acid

: 937018-48-9
N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; for 72h;
DOI:10.1039/b615628b

Reference yield:

: 937018-47-8
N-[4-[4-[4-[(2-aminoethyl)ethylamino]phenyl]buta-1,3-dienyl]phenyl]benzamide

: 937018-48-9
N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / aq. NaOH / ethanol / 12 h / Heating

2: 57 percent / Et₃N; HBTU / dimethylformamide / 72 h

With sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/b615628b

Reference yield:

: 937018-45-6
N-[4-[4-[4-[ethyl-(2-hydroxyethyl)amino]phenyl]buta-1,3-dienyl]phenyl]benzamide

: 937018-48-9
N-[2-[[4-[4-(4-aminophenyl)buta-1,3-dienyl]phenyl]ethylamino]ethyl]-1-(6-amino-9H-purin-9-yl)-1-deoxy-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 3 h / 0 °C

2: 0.759 g / NaN₃ / CH₂Cl₂; N,N-dimethyl-acetamide / 12 h / Heating

3: 100 percent / Ph₃P / toluene / 7 h / Heating

4: 75 percent / aq. NaOH / ethanol / 12 h / Heating

5: 57 percent / Et₃N; HBTU / dimethylformamide / 72 h

With pyridine; sodium hydroxide; sodium azide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b615628b