2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

Base Information

Chemical Name:2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid
CAS No.:1334472-83-1
Molecular Formula:C₁₈H₃₂N₂O₆
Molecular Weight:372.462
Hs Code.:

Synonyms:2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

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Chemical Property of 2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

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Technology Process of 2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

There total 4 articles about 2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1334472-80-8
(4aS,8aS)-di-tert-butyl 3-oxooctahydrocinnoline-1,2-dicarboxylate

: 1334472-83-1
2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ja206819y

Reference yield:

: 1334472-51-3
(S)-di-tert-butyl 3-oxo-6,7,8,8a-tetrahydrocinnoline-1,2(3H,5H)-dicarboxylate

: 1334472-83-1
2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / ethanol; ethyl acetate / 12 h / 20 °C

2: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With palladium on carbon; hydrogen; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1021/ja206819y

Reference yield:

: 870-50-8
di-tert-butyl-diazodicarboxylate

: 1334472-83-1
2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: TMS-quinidine hydrochloride; triethylamine / toluene / -40 °C / Inert atmosphere

2: palladium on carbon; hydrogen / ethanol; ethyl acetate / 12 h / 20 °C

3: sodium hydroxide / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With palladium on carbon; TMS-quinidine hydrochloride; hydrogen; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; ethyl acetate; toluene;
DOI:10.1021/ja206819y