[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

Base Information

Chemical Name:[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester
CAS No.:171049-45-9
Molecular Formula:C₃₆H₃₅N₅O₆
Molecular Weight:633.704
Hs Code.:

[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

Synonyms:[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

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Chemical Property of [7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

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Technology Process of [7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

There total 12 articles about [7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: Cbz p-amidinoaniline

: (7-Chlorocarbonyl-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester

: 171049-45-9
[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

Guidance literature:: With pyridine; In dichloromethane;
DOI:10.1021/jm00001a003

Reference yield:

: 3113-71-1
3-methyl-4-nitrobenzoic acid

: 171049-45-9
[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 82 percent / PhSO₂Cl, pyridine

2: N-bromosuccinimide, (PhCO₂)2 / CCl₄ / Heating

3: NaHCO₃ / tetrahydrofuran

4: 100 percent / CH₂Cl₂

5: 91 percent / H₂ / Pd/C / ethyl acetate

6: methanol

7: H₂ / 10percent Pd/C

8: trifluoroacetic acid / CH₂Cl₂

9: 87 percent / CH₃ONa / methanol

10: SOCl₂ / Heating

11: 70 percent / pyridine / CH₂Cl₂

With pyridine; N-Bromosuccinimide; thionyl chloride; hydrogen; sodium methylate; sodium hydrogencarbonate; benzenesulfonyl chloride; trifluoroacetic acid; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate;
DOI:10.1021/jm00001a003

Reference yield:

: 64-04-0
phenethylamine

: 171049-45-9
[7-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: NaHCO₃ / tetrahydrofuran

2: 100 percent / CH₂Cl₂

3: 91 percent / H₂ / Pd/C / ethyl acetate

4: methanol

5: H₂ / 10percent Pd/C

6: trifluoroacetic acid / CH₂Cl₂

7: 87 percent / CH₃ONa / methanol

8: SOCl₂ / Heating

9: 70 percent / pyridine / CH₂Cl₂

With pyridine; thionyl chloride; hydrogen; sodium methylate; sodium hydrogencarbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00001a003