(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Base Information

Chemical Name:(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)
CAS No.:1622917-95-6
Molecular Formula:C₂₂H₂₃ClN₄O₄S₂
Molecular Weight:507.034
Hs Code.:

Synonyms:(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Suppliers and Price of (4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

There total 7 articles about (4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: ethyl 4-[2-({6-chloro-2-[(1-ethoxy-1-oxooctan-2-yl)sulfanyl]pyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoate

: 1622917-95-6
(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 60 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.06.077

Reference yield:

: 916482-24-1
ethyl 2-[(4,6-dihydroxypyrimidin-2-yl)sulfanyl]octanoate

: 1622917-95-6
(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; N,N-diethylaniline / 6 h / 90 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium carbonate / toluene; water / 18 h / 90 °C / Inert atmosphere

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sodium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.bmcl.2014.06.077

Reference yield:

: 138286-76-7,5445-29-4
ethyl-2-bromooctanoate

: 1622917-95-6
(4-[2-({2-[(1-carboxyheptyl)sulfanyl]-6-chloropyrimidin-4-yl}amino)-1,3-thiazol-4-yl]benzoic acid)

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 3 h / 90 °C

2: trichlorophosphate; N,N-diethylaniline / 6 h / 90 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium carbonate / toluene; water / 18 h / 90 °C / Inert atmosphere

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sodium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N-diethylaniline; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2014.06.077