2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Base Information

• Chemical Name: 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide
• CAS No.: 936633-51-1
• Molecular Formula: C₃₆H₄₀N₄O₃
• Molecular Weight: 576.739

Synonyms:2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Chemical Property of 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide

There total 6 articles about 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N¹-(3-naphthalen-1-yl-propyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-phenethyl-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid tert-butyl ester (936633-52-2) → 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N1-(3-naphthalen-1-yl-propyl)-succinamide (936633-51-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/jm0614073

Reference yield:

6-bromo-2-tert-butoxycarbonylamino-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester → 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N1-(3-naphthalen-1-yl-propyl)-succinamide (936633-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / cesium carbonate; molecular sieves 4 Angstroem / P(t-Bu)3; Pd₂(dba)3 / dioxane / 18 h / Heating

2: 100 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

3: 85 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 20 °C

4: N-hydroxybenzotriazole hydrate; N,N'-diisopropylcarbodiimide / dimethylformamide / 15 h / 20 °C

5: 32.3 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 - 20 °C

With lithium hydroxide; 4 A molecular sieve; hydrogen; benzotriazol-1-ol; caesium carbonate; trifluoroacetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0614073

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 2-[(2-amino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N1-(3-naphthalen-1-yl-propyl)-succinamide (936633-51-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / cesium carbonate; molecular sieves 4 Angstroem / P(t-Bu)3; Pd₂(dba)3 / dioxane / 18 h / Heating

2: 100 percent / hydrogen / Pd/C / ethyl acetate / 20 °C

3: 85 percent / lithium hydroxide monohydrate / tetrahydrofuran; methanol; H₂O / 20 °C

4: N-hydroxybenzotriazole hydrate; N,N'-diisopropylcarbodiimide / dimethylformamide / 15 h / 20 °C

5: 32.3 mg / trifluoroacetic acid / CH₂Cl₂ / 1 h / 0 - 20 °C

With lithium hydroxide; 4 A molecular sieve; hydrogen; benzotriazol-1-ol; caesium carbonate; trifluoroacetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0614073

upstream raw materials:

{2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-phenethyl-1,2,3,4-tetrahydro-naphthalen-2-yl}-carbamic acid tert-butyl ester

styrene

2-tert-butoxycarbonylamino-6-styryl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid methyl ester

2-tert-butoxycarbonylamino-6-phenethyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

Downstream raw materials:

N-{2-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-6-phenethyl-1,2,3,4-tetrahydro-naphthalen-2-yl}-3-[4-(di-tert-butoxy-phosphorylmethyl)-benzyl]-succinamic acid tert-butyl ester

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