3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

Base Information

Chemical Name:3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline
CAS No.:1360684-76-9
Molecular Formula:C₂₆H₃₁ClN₄O₂S
Molecular Weight:499.077
Hs Code.:

Synonyms:3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

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Chemical Property of 3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

Chemical Property:

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Technology Process of 3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

There total 3 articles about 3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360625-60-0
4-[2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl]piperidine-1-carboxylic acid tert-butyl ester

: 159182-40-8
quinoline-3-sulfonyl chloride

: 1360684-76-9
3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

Guidance literature:: 4-[2-(4-(4-chlorophenyl)piperazin-1-yl)ethyl]piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane;

quinoline-3-sulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Cooling;
DOI:10.1016/j.bmc.2011.12.039

Reference yield:

: 89151-44-0
4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester

: 1360684-76-9
3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 13 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: triethylamine / tetrahydrofuran; toluene / 20 h / Reflux

3.1: trifluoroacetic acid / dichloromethane

3.2: 0 °C / Cooling

With pyridine; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.12.039

Reference yield:

: 89151-45-1
tert-butyl-4-(2-(tosyloxy)ethyl)piperidine-1-carboxylate

: 1360684-76-9
3-(4-{2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl}piperidine-1-sulfonyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran; toluene / 20 h / Reflux

2.1: trifluoroacetic acid / dichloromethane

2.2: 0 °C / Cooling

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.12.039