(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

Base Information

Chemical Name:(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate
CAS No.:1428063-96-0
Molecular Formula:C₂₂H₁₇N₅O₂
Molecular Weight:383.409
Hs Code.:

Synonyms:(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

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Chemical Property of (E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

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Technology Process of (E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

There total 4 articles about (E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 183319-38-2
N⁴-(3-ethynylphenyl)quinazoline-4,6-diamine

: 94-05-3,42466-69-3
2-cyano-3-ethoxyacrylic acid ethyl ester

: 1428063-96-0
(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

Guidance literature:: In ethanol; for 3h; Reflux;
DOI:10.1016/j.ejmech.2012.10.017

Reference yield:

: 183321-64-4
N-(3-ethynylphenyl)-6-nitroquinazolin-4-amine

: 1428063-96-0
(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium dithionite; ammonium hydroxide / water / 0.5 h / Reflux

2: ethanol / 3 h / Reflux

With ammonium hydroxide; sodium dithionite; In ethanol; water;
DOI:10.1016/j.ejmech.2012.10.017

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1428063-96-0
(E)-ethyl 3-[4-(3-ethynylphenylamino)quinazolin-6-ylamino]-2-cyanoacrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.5 h / Reflux

2: acetic acid / 2 h / Reflux

3: sodium dithionite; ammonium hydroxide / water / 0.5 h / Reflux

4: ethanol / 3 h / Reflux

With ammonium hydroxide; sodium dithionite; acetic acid; In ethanol; water;
DOI:10.1016/j.ejmech.2012.10.017