(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

Base Information

Chemical Name:(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate
CAS No.:1434302-14-3
Molecular Formula:C₃₁H₂₅F₁₂NO₄Si
Molecular Weight:731.61
Hs Code.:

Synonyms:(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

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Chemical Property of (1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

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Technology Process of (1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

There total 2 articles about (1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1434302-11-0
(2S,4S)-benzyl 2-(bis(3,5-bis(trifluoromethyl)phenyl)(hydroxy)methyl)-4-hydroxypyrrolidine-1-carboxylate

: 75-78-5,30107-43-8
dimethylsilicon dichloride

: 1434302-14-3
(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 19h; Inert atmosphere;
DOI:10.1002/adsc.201200922

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1434302-14-3
(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylazodicarboxylate; triphenylphosphine / toluene; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2.1: magnesium / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux

2.2: 17 h / 0 - 20 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 19 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; magnesium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1002/adsc.201200922

Reference yield: 55.0%

: 1434302-14-3
(1S,6S)-benzyl 5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane-7-carboxylate

: 1434302-18-7
(1S,6S)-5,5-bis(3,5-bis(trifluoromethyl)phenyl)-3,3-dimethyl-2,4-dioxa-7-aza-3-silabicyclo[4.2.1]nonane

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 24h;
DOI:10.1002/adsc.201200922