4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

Base Information

Chemical Name:4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate
CAS No.:1334335-82-8
Molecular Formula:C₁₆H₂₂ClN₂O₄PS₂
Molecular Weight:436.92
Hs Code.:

Synonyms:4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

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Technology Process of 4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

There total 1 articles about 4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 4-chlorophenyl-[(S)-4-isopropylthiazolidine-2-thione]phosphorochloridate

: 2491-20-5
L-alanine methyl ester hydrochloride

: C₁₈H₁₈Cl₂NO₃PS₂

: 1334335-82-8
4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

: 1334335-71-5
4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100614

Reference yield: 26.0%

: 1334335-82-8
4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate

: 3056-17-5
stavudin

: 728930-05-0
5'-O-(3'-'deoxy-2',3'-didehydrothymidinyl)-O-(4-chlorophenyl)-N-[(S)-methoxyalaninyl]-phosphoramidate

Guidance literature:: stavudin; With tert-butylmagnesium chloride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

4-chlorophenyl-N-[(S)-alaninyl]-(4-isopropylthiazolidine-2-thione)phosphorodiamidate; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; optical yield given as %de; diastereospecific reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100614