2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester
CAS No.:474686-33-4
Molecular Formula:C₂₃H₃₁N₃O₇
Molecular Weight:461.515
Hs Code.:

2-(1-benzyloxycarbonylamino-5-<i>tert</i>-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

Synonyms:2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

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Chemical Property of 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

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Technology Process of 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

There total 6 articles about 2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 84860-21-9
(S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester

: 474686-33-4
2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

Guidance literature:: (S)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-hydroxy-propionic acid methyl ester; With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at -30 ℃; for 4h;

With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; at -40 - -5 ℃; Further stages.;
DOI:10.1021/ol026463m

Reference yield: 85.0%

: 956111-87-8
C₂₃H₃₃N₃O₇

: 474686-33-4
2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃;

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 474686-33-4
2-(1-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentyl)-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / benzotriazol-1-yl-oxy-tris(dimethylamino) phosphonium PF₆; diisopropylethyl amine / dimethylformamide / 4 h / 20 °C

2.1: [bis(2-methoxyethyl)amino]-sulfur trifluoride / CH₂Cl₂ / 4 h / -30 °C

2.2: 89 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / -40 - -5 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol026463m