(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1464150-87-5
Molecular Formula:C₂₅H₂₃N₉O
Molecular Weight:465.517
Hs Code.:

Synonyms:(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

There total 5 articles about (4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1464150-41-1
4-(6-(4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)benzonitrile

: 1464150-87-5
(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

Reference yield:

: 1464153-41-0
(4-(imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 1464150-87-5
(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile; dichloromethane / 1.5 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

3: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 18 h / 100 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; potassium carbonate; ammonium chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 832114-06-4
(4-methylpiperazine-1-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]methanone

: 1464150-87-5
(4-(3-(4-(2H-tetrazol-5-yl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / water / 4 h / 90 °C

2: N-Bromosuccinimide / acetonitrile; dichloromethane / 1.5 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

4: ammonium chloride; sodium azide / N,N-dimethyl-formamide / 18 h / 100 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;