4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

Base Information

Chemical Name:4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride
CAS No.:250292-78-5
Molecular Formula:C₂₀H₂₂FNO₇
Molecular Weight:407.396
Hs Code.:

Synonyms:4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

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Chemical Property of 4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

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Technology Process of 4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

There total 5 articles about 4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 250292-68-3
4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl alcohol

: 250292-78-5
4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 0.75h;
DOI:10.1021/jo991085t

Reference yield:

: 4101-32-0
4',5'-dimethoxy-2'-nitroacetophenone

: 250292-78-5
4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / sodium borohydride / ethanol / 19 h

2.1: pyridine / CH₂Cl₂

2.2: 49 percent / pyridine / CH₂Cl₂

3.1: 99 percent / sodium borohydride / ethanol / 1.5 h / 20 °C

4.1: 63 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.75 h

With pyridine; sodium tetrahydroborate; diethylamino-sulfur trifluoride; In ethanol; dichloromethane; 1.1: Reduction / 2.1: Acylation / 2.2: Acylation / 3.1: Reduction / 4.1: Fluorination;
DOI:10.1021/jo991085t

Reference yield:

: 37942-55-5
1-(4,5-Dimethoxy-2-nitrophenyl)-ethanol

: 250292-78-5
4-(4',5'-dimethoxy-α'-methyl-2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂

1.2: 49 percent / pyridine / CH₂Cl₂

2.1: 99 percent / sodium borohydride / ethanol / 1.5 h / 20 °C

3.1: 63 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.75 h

With pyridine; sodium tetrahydroborate; diethylamino-sulfur trifluoride; In ethanol; dichloromethane; 1.1: Acylation / 1.2: Acylation / 2.1: Reduction / 3.1: Fluorination;
DOI:10.1021/jo991085t