(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester
CAS No.:781662-40-6
Molecular Formula:C₂₄H₂₃N₃O₃
Molecular Weight:401.465
Hs Code.:

Synonyms:(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Suppliers and Price of (S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

There total 1 articles about (S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 79261-58-8
(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester

: 781662-40-6
(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: (S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-benzyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at 0 ℃; for 1h;

1,2-diamino-benzene; In dichloromethane; for 3h;
DOI:10.1021/jm030548r

Reference yield:

: 781662-40-6
(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

: 781662-43-9
[2-[3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-1-(4-tert-butoxybenzyl)-2-oxo-ethyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 1.5 h / Heating

2: 74 percent / TMSI / CHCl₃ / 20 °C

3: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 16 h / 20 °C

With trimethylsilyl iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm030548r

Reference yield:

: 781662-40-6
(S)-3-(2-aminophenylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

: (2S)-2-amino-1-[(3R)-3-(1H-benzoimidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-3-(4-hydroxyphenyl)propan-1-one bis-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 1.5 h / Heating

2: 74 percent / TMSI / CHCl₃ / 20 °C

3: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 16 h / 20 °C

4: 0 °C

With trimethylsilyl iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In chloroform; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm030548r