<1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al

Base Information

• Chemical Name: <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al
• CAS No.: 128684-97-9
• Molecular Formula: C₅₈H₁₀₁NO₁₀Si₂
• Molecular Weight: 1028.61
• Mol file: 128684-97-9.mol

Synonyms:<1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al

Chemical Property of <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al

There total 32 articles about <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

<1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8R>-3--2,4-dimethyl-8-(hydroxymethyl)-7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-5-<(triisopropylsilyl)oxy>-1,10-undecadiene (128684-96-8) → <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al (128684-97-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;

DOI:10.1021/ja00170a024

Reference yield:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) → <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al (128684-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) DL-tartaric acid, 2.) Et₃N / 1.) EtOH, 2.) THF, H₂O, RT, 40 h

2: 81 percent / dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂ / 19 h / -20 °C

3: 99 percent / Zn, NH₄Cl / ethanol / 1 h / 35 - 40 °C

4: 97 percent / 1.) oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

With oxalyl dichloride; ammonium chloride; 4-pyrrolidin-1-ylpyridine; dimethyl sulfoxide; tartaric acid; triethylamine; dicyclohexyl-carbodiimide; zinc; In ethanol; dichloromethane;

DOI:10.1021/ja00170a024

Reference yield:

triisopropylsilyl trifluoromethanesulfonate (80522-42-5) → <1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8S>-3--7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-2,4-dimethyl-8-(2-propen-1-yl)-5-<(triisopropylsilyl)oxy>-1-nonen-9-al (128684-97-9)

Guidance literature:

Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

2: 1.) O₃, pyridine, 2.) Me₂S / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) RT, 13 h

4: 81 percent / dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂ / 19 h / -20 °C

5: 99 percent / Zn, NH₄Cl / ethanol / 1 h / 35 - 40 °C

6: 97 percent / 1.) oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

With pyridine; oxalyl dichloride; dimethylsulfide; ammonium chloride; 4-pyrrolidin-1-ylpyridine; ozone; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; zinc; In ethanol; dichloromethane;

DOI:10.1021/ja00170a024

upstream raw materials:

<1(1R,3R,4R),1E,3(2S),3S,4S,5S,7S,8R>-3--2,4-dimethyl-8-(hydroxymethyl)-7-<(4-methoxybenzyl)oxy>-1-<3-methoxy-4-<(triisopropylsilyl)oxy>cyclohex-1-yl>-5-<(triisopropylsilyl)oxy>-1,10-undecadiene

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

triisopropylsilyl trifluoromethanesulfonate

(4R,5S)-5-ethenyl-4-methoxytetrahydro-2H-pyran-2-one

Downstream raw materials:

C₈₂H₁₄₉NO₁₂S₂Si₃

C₈₂H₁₄₉NO₁₂S₂Si₃