methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

Base Information

Chemical Name:methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate
CAS No.:865134-79-8
Molecular Formula:C₃₆H₃₆N₄O₆S₂
Molecular Weight:684.837
Hs Code.:

Synonyms:methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

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Chemical Property of methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

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Technology Process of methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

There total 4 articles about methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: methyl 3-{4-[[(2-nitrophenyl)sulfonyl](4-{[(1E)-(4-phenyl-1,3-thiazol-2-yl)methylene]amino}benzyl)amino]phenyl}propanoate

: 123-38-6
propionaldehyde

: 865134-79-8
methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

Guidance literature:: methyl 3-{4-[[(2-nitrophenyl)sulfonyl](4-{[(1E)-(4-phenyl-1,3-thiazol-2-yl)methylene]amino}benzyl)amino]phenyl}propanoate; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 60h;

propionaldehyde; In 1,2-dichloro-ethane; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane;

Reference yield:

: 75390-44-2
4-Phenyl-2-Thiazolecarboxaldehyde

: 865134-79-8
methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 20 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 60 h / 20 °C

3.2: 3 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;

Reference yield:

: 2393-17-1
3-(4-aminophenyl)propionic acid

: 865134-79-8
methyl 3-[4-([(2-nitrophenyl)sulfonyl]{4-[[(4-phenyl-1,3-thiazol-2-yl)methyl](propyl)amino]benzyl}amino)phenyl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 0.17 h / 0 °C

1.2: 18 h / 20 °C

2.1: pyridine / 45 h / 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 60 h / 20 °C

4.2: 3 h / 20 °C

With pyridine; thionyl chloride; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;