N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

Base Information

Chemical Name:N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol
CAS No.:1332461-75-2
Molecular Formula:C₁₈H₂₄Cl₂N₄O₅
Molecular Weight:447.318
Hs Code.:

Synonyms:N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

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Chemical Property of N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

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Technology Process of N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

There total 5 articles about N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 33133-31-2
3,4-dichloro-1-(prop-2-yn-1-yloxy)benzene

: 1332461-53-6
N-(3-azidopropyl)-1,5-dideoxy-1,5-imino-D-glucitol

: 1332461-75-2
N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

Guidance literature:: With copper(II) sulfate; sodium L-ascorbate; In 1,4-dioxane; water; at 80 ℃; for 0.75h; Microwave irradiation;
DOI:10.1021/jo201125x

Reference yield:

: 78136-16-0,14233-48-8
2,3,4,6-tetra-O-benzyl-D-glucitol

: 1332461-75-2
N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

1.2: -78 - 20 °C

2.1: sodium cyanoborohydride / Microwave irradiation

3.1: hydrogenchloride; hydrogen; palladium(II) hydroxide / methanol; water / 16 h / 760.05 Torr

4.1: triflic azide; potassium carbonate; copper(II) sulfate / methanol; dichloromethane; water / 24 h / 20 °C

5.1: copper(II) sulfate; sodium L-ascorbate / 1,4-dioxane; water / 0.75 h / 80 °C / Microwave irradiation

With hydrogenchloride; oxalyl dichloride; triflic azide; hydrogen; palladium(II) hydroxide; sodium cyanoborohydride; potassium carbonate; copper(II) sulfate; dimethyl sulfoxide; sodium L-ascorbate; In 1,4-dioxane; methanol; dichloromethane; water; 1.1: Swern oxidation / 1.2: Swern oxidation;
DOI:10.1021/jo201125x

Reference yield:

: 1119249-25-0
N-(3-azidopropyl)-2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

: 1332461-75-2
N-(3-(4-(3,4-dichlorophenoxymethyl)-1H-1,2,3-triazol-1-yl)propyl)-1,5-dideoxy-1,5-imino-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; hydrogen; palladium(II) hydroxide / methanol; water / 16 h / 760.05 Torr

2: triflic azide; potassium carbonate; copper(II) sulfate / methanol; dichloromethane; water / 24 h / 20 °C

3: copper(II) sulfate; sodium L-ascorbate / 1,4-dioxane; water / 0.75 h / 80 °C / Microwave irradiation

With hydrogenchloride; triflic azide; hydrogen; palladium(II) hydroxide; potassium carbonate; copper(II) sulfate; sodium L-ascorbate; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/jo201125x